So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hu, Dejin; Liu, Sufang; Huang, Tonghui; Tu, Haiyang; Li, Weiguo; Zhu, Xiaolei; Zhang, Aidong researched the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ).Application of 438565-33-4.They published the article 《Synthesis and herbicidal activities of Nε-[(anilino)carbonyl]-Nα-[(3-phenyl-5-isoxazolyl)carbonyl]lysine》 about this compound( cas:438565-33-4 ) in Youji Huaxue. Keywords: D1 protease inhibitor herbicide isoxazole lysine preparation. We’ll tell you more about this compound (cas:438565-33-4).
Recently the D1 protease located in the thylakoid membranes of higher plants was found to be a potential herbicide target and based on a lead compound [Nα-[(5-isoxazolyl)carbonyl]lysine, D1 protease inhibitor] a series of novel N5-[(phenylamino)carbonyl]-N2-[(3-phenyl-5-isoxazolyl)carbonyl]lysine derivatives were designed. The synthesis of the target compounds was achieved using as reactants 3-phenyl-5-isoxazolecarbonyl chlorides and N5-[(phenylamino)carbonyl]lysine and the products thus obtained were confirmed by IR, 1H-NMR and elemental anal. The biol. activity was examined in vivo and it was discovered that most compounds possessed moderate herbicidal activity. Meanwhile, the e activity of one compound was evaluated against spinach D1 protease (i.e., thylakoid protein precursor processing peptidase, chloroplast protein precursor-processing proteinase, photosystem D1 protein precursor carboxyl-terminal processing proteinase, proteinase CtpA) and the result showed its inhibiting effect against this enzyme.
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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method