So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yong, Jian-Ping; Lu, Can-Zhong; Wu, Xiaoyuan researched the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ).Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol.They published the article 《Potential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity》 about this compound( cas:438565-33-4 ) in Anti-Cancer Agents in Medicinal Chemistry. Keywords: cancer cell isoxazole quinazoline anticancer agent. We’ll tell you more about this compound (cas:438565-33-4).
14 New structures of isoxazole-moiety-containing quinazoline derivatives(3a∼3n) were synthesized for the first time and characterized by IR, 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, most compounds showed good to excellent anticancer activity, especially 3d, 3i, 3k and 3m exhibited the more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising drug candidates for development of anticancer drugs.
The article 《Potential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity》 also mentions many details about this compound(438565-33-4)Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol, you can pay attention to it or contacet with the author([email protected]) to get more information.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method