Tag: M.W:100-200

HPLC of Formula: 27828-71-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Poly[[diaquabis(μ-oxalato-κ4O1,O2:O1′,O2′)bis(μ3-5-oxidopyridin-1-ium-3-carboxylato-κ3O3:O3′:O5)diholmium(III)] dihydrate]. Author is Mi, Jun-Long; Huang, Jing; Chen, Hong-Ji.

The crystal structure of Poly[[diaquabis(μ-oxalato-κ4O1,O2:O1′,O2′)bis(μ3-5-oxidopyridin-1-ium-3-carboxylato-κ3O3:O3′:O5)diholmium(III)] dihydrate] has been determined The HoIII atom was coordinated by three O atoms from three 5-hydroxynicotinate ligands, four O atoms from two oxalate ligands, each lying on an inversion center, and one water mol. in a distorted square-antiprismatic geometry. The 5-hydroxynicotinate ligand was protonated at the N atom and deprotonated at the hydroxy group. The HoIII atoms were bridged by the carboxylate and phenolate O atoms, forming a three-dimensional framework. N-H···O and O-H···O hydrogen bonds, as well as π-π interactions between the pyridine rings [centroid-centroid distance = 3.794(2) Å], were observed

This compound(5-Hydroxynicotinic acid)HPLC of Formula: 27828-71-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Cyano-2-methylpropanoic acid( cas:22426-30-8 ) is researched.Reference of 2-Cyano-2-methylpropanoic acid.Eberson, Lennart; Nilsson, Sven published the article 《Kolbe electrolytic synthesis. VIII. Electrolysis of α-cyanocarboxylates》 about this compound( cas:22426-30-8 ) in Acta Chemica Scandinavica (1947-1973). Keywords: kolbe electrolysis; electrolysis Kolbe; cyanocarboxylate electrolysis; carboxylate electrolysis. Let’s learn more about this compound (cas:22426-30-8).

Isopropyl-, tert-butyl-, cyclohexyl-, and dimethylcyanoacetic acid were electrolyzed in methanolic solution and the radical coupling products determined quant. tert-Butylcyanoacetic acid was also electrolyzed in water, acetonitrile, and N,N-dimethylformamide. From this acid a very low yield of a rearrangement product, 2-cyano-3-methyl-2-butene, was obtained on electrolysis in methanol at a Pt anode; the same low yield was observed when a carbon anode was used. The behavior of anodically generated α-cyanoalkyl radicals is very similar to that of α-cyanoalkyl radicals generated in homogeneous solution, both with regard to the stereochemistry of the reaction and to the proportion between C-to-C and C-to-N-coupling products.

This compound(2-Cyano-2-methylpropanoic acid)Reference of 2-Cyano-2-methylpropanoic acid was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The tautomerism of N-heteroaromatic hydroxy compounds. III. Ionization constants》. Authors are Mason, S. F..The article about the compound:Isoquinolin-6-olcas:7651-82-3,SMILESS:OC1=CC2=C(C=NC=C2)C=C1).Computed Properties of C9H7NO. Through the article, more information about this compound (cas:7651-82-3) is conveyed.

cf. C.A. 52, 4324b. Acidic and basic ionization constants are reported for a number of N-heteroaromatic hydroxy compounds and their O- and N-Me derivatives From the measured and from published values, tautomeric equilibrium constants (Kt = [NH form]/[OH form]) were estimated for the monoaza compounds, and for the diaza compounds with not more than one N atom conjugated with the OH group. For the diazacompds. with a ring-N atom placed both ortho and para to the OH group, the equilibrium constant (Kop = [ο-quinonoid NH form]/[p-quinonoid NH form]) was similarly estimated Such constants agree, to within an order of magnitude, with those determined spectrophotometrically. The ionization and tautomeric constants vary with the π-electron energies of the species in equilibrium Absorption spectra were measured with a Hilger Uvispek H700/305 Quartz Spectrophotometer, and aqueous solutions with pH values 2 units less than pK1 value of the 63 compounds examined Ionization constants were determined by potentiometric titration at 20° under N, a Cambridge pH meter being used with glass and calomel electrodes. The ionization constants of the N-heteroaromatic hydroxy compounds were measured at 0.004M and those of the O- and N-Me derivatives at 0.01M.

This compound(Isoquinolin-6-ol)Computed Properties of C9H7NO was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors, the main research direction is benzoylpiperidine preparation reversible monoacylglycerol lipase inhibitor human antitumor; Benzoylpiperidine derivatives; MAGL; Monoacylglycerol lipase inhibitors.Safety of 5-Hydroxynicotinic acid.

An interesting enzyme of the endocannabinoid system is monoacylglycerol lipase (MAGL). This enzyme, which metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG), has attracted great interest due to its involvement in several physiol. and pathol. processes, such as cancer progression. Exptl. evidences highlighted some drawbacks associated with the use of irreversible MAGL inhibitors in vivo, therefore the research field concerning reversible inhibitors is rapidly growing. In the present manuscript, the class of benzoylpiperidine-based MAGL inhibitors was further expanded and optimized. Enzymic assays identified some compounds in the low nanomolar range and steered mol. dynamics simulations predicted the dissociation itinerary of one of the best compounds from the enzyme, confirming the observed structure-activity relationship. Biol. evaluation, including assays in intact U937 cells and competitive activity-based protein profiling experiments in mouse brain membranes, confirmed the selectivity of the selected compounds for MAGL vs. other components of the endocannabinoid system. Future studies on the potential use of these compounds in the clin. setting are also supported by the inhibition of cell growth observed both in cancer organoids derived from high grade serous ovarian cancer patients and in pancreatic ductal adenocarcinoma primary cells, which showed genetic and histol. features very similar to the primary tumors.

《Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Hydroxynicotinic acid)Safety of 5-Hydroxynicotinic acid.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Safety of 5-Hydroxynicotinic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Hydrothermal synthesis and crystal structure of a 2D zinc(II) coordination polymer with 5-hydroxynicotinic acid. Author is Zhang, Jin; Chen, Hong-Ji; Huang, Jing.

The title compound, [Zn(5-hydroxynicotinate)2·2H2O]n, was synthesized by reacting zinc sulfate vitriol with 5-hydroxynicotinic acid under hydrothermal conditions, and its structure was determined by x-ray crystallog. with the following data: monoclinic, space group C12H12N2O8Zn, Mr = 377.61, a 10.223(3), b 10.319(3), c 13.613(4) Å, β 105.922(6)°, Z = 4, F(000) = 768, dc = 1.816 g/cm3, μ(MoKα) = 1.826 mm-1, the final R = 0.0401 and Rw = 0.1380 for 1157 observed reflections (I > 2σ(I)). In the structure of the title compound, the ZnII ion located in an inversion center lies in a distorted tetrahedral environment at a N2O2 coordination mode, and the 5-hydroxynicotinic acid ligand links symmetry-related ZnII ions at a μ2-N,O bridging way forming a two-dimensional covalent structure. In the crystal, solvent water mols. form intermol. O-H···O hydrogen bonds and pyridine rings of adjacent layers form π-π stacking (3.346 Å), which connect adjacent two-dimensional sheets into a three-dimensional supramol. network.

This compound(5-Hydroxynicotinic acid)Safety of 5-Hydroxynicotinic acid was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Application of 27828-71-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Chemical constituents in n-butanol extracts of Cheanomeles speciosa (Sweet) Nakai. Author is Li, Xia; Yang, Ying-bo; Xi, Zhong-xin; Sun, Lei; Chen, Wan-sheng; Sun, Lian-na.

Chem. constituents in n-butanol extracts of Chaenomeles speciosa were investigated. Multi-chromatog. methods including Silicagel column chromatog. and Sephadex LH-20 gel permeation were employed for the isolation and purification The structures were identified on the basis of chem. evidence and spectral data. Eight compounds were isolated and identified as 1,2,4-Benzenetriol (1), gallic acid (2), epi-quinide (3), 5-Hydroxynicotinic acid (4), p-coumaric acids glucosyl esters (5), p-hydroxybenzoic acid glucoside (6), (6S,9R)-roseoside (7) and Vomifolioll-O-β-D-xylopyranosy-6-O-β-D-glucopyranoside (8). Compounds 1-6 were obtained from this genus for the first time.

This compound(5-Hydroxynicotinic acid)Application of 27828-71-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Use of 8-Substituted-FAD Analogues To Investigate the Hydroxylation Mechanism of the Flavoprotein 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase, published in 2004-04-06, which mentions a compound: 27828-71-3, Name is 5-Hydroxynicotinic acid, Molecular C6H5NO3, Name: 5-Hydroxynicotinic acid.

2-Methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) oxygenase (MHPCO) is a flavoprotein that catalyzes the oxygenation of MHPC to form α-(N-acetylaminomethylene)-succinic acid. Although formally similar to the oxygenation reactions catalyzed by phenol hydroxylases, MHPCO catalyzes the oxygenation of a pyridyl derivative rather than a simple phenol. Therefore, in this study, the mechanism of the reaction was investigated by replacing the natural cofactor FAD with FAD analogs having various substituents (-Cl, -CN, -NH2, -OCH3) at the C8-position of the isoalloxazine. Thermodn. and catalytic properties of the reconstituted enzyme were investigated and found to be similar to those of the native enzyme, validating that these FAD analogs are reasonable to be used as mechanistic probes. Dissociation constants for the binding of MHPC or the substrate analog 5-hydroxynicotinate (5HN) to the reconstituted enzymes indicate that the reconstituted enzymes bind well with ligands. Redox potential values of the reconstituted enzymes were measured and found to be more pos. than the values of free FAD analogs, which correlated well with the electronic effects of the 8-substituents. Studies of the reductive half-reaction of MHPCO have shown that the rates of flavin reduction by NADH could be described as a parabolic relationship with the redox potential values of the reconstituted enzymes, which is consistent with the Marcus electron transfer theory. Studies of the oxidative half-reaction of MHPCO revealed that the rate of hydroxylation depended upon the different analogs employed. The rate constants for the hydroxylation step correlated with the calculated pKa values of the 8-substituted C(4a)-hydroxyflavin intermediates, which are the leaving groups in the oxygen transfer step. It was observed that the rates of hydroxylation were greater when the pKa values of C(4a)-hydroxyflavins were lower. Although these results are not as dramatic as those from analogous studies with p-hydroxybenzoate hydroxylase, they are consistent with the model that the oxygenation reaction of MHPCO occurs via an electrophilic aromatic substitution mechanism analogous to the mechanisms for p-hydroxybenzoate and phenol hydroxylases.

This compound(5-Hydroxynicotinic acid)Name: 5-Hydroxynicotinic acid was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase, published in 2013-02-15, which mentions a compound: 7651-82-3, Name is Isoquinolin-6-ol, Molecular C9H7NO, Electric Literature of C9H7NO.

Rdc2 of Pochonia chlamydosporia is the 1st flavin-dependent halogenase identified from fungi. Based on the reported structure of the bacterial halogenase CmlS, the authors built a homol. model for Rdc2. The model suggested an open substrate binding site that was capable of binding the natural substrate, monocillin II, and possibly other mols. such as 4-hydroxyisoquinoline (I) and 6-hydroxyisoquinoline (II). In vitro and in vivo halogenation experiments confirmed that I and II could be halogenated at the position ortho to the OH group, leading to the synthesis of the chlorinated isoquinolines, 3-chloro-4-hydroxyisoquinoline and 5-chloro-6-hydroxyisoquinoline, resp., which further expanded the spectrum of identified substrates of Rdc2. This work revealed that Rdc2 is a useful biocatalyst for the synthesis of various halogenated compounds

This compound(Isoquinolin-6-ol)Electric Literature of C9H7NO was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A highly efficient solution and solid state ESIPT fluorophore and its OLED application, published in 2021, which mentions a compound: 27828-71-3, Name is 5-Hydroxynicotinic acid, Molecular C6H5NO3, Recommanded Product: 27828-71-3.

We present herein the synthesis and photophysics of 2,2′-bipyridine-3,3′-diol-5,5′-dicarboxylic acid Et ester (BP(OH)2DCEt2), an excited state intramol. proton transfer (ESIPT)-based fluorophore featuring two identical intramol. hydrogen bonds. BP(OH)2DCEt2 emits efficiently not only in solution, including protic solvents (λem = 521 nm, Φf = 40 to 75%), but also in crystalline state (λem = 530 nm, Φf = 51%). In addition, its saponified form (Na2BP(OH)2DC) is highly fluorescent in water (λem = 490 nm, Φf = 51%). Finally, the good electroluminescence performance of BP(OH)2DCEt2 is also demonstrated in an OLED device.

This compound(5-Hydroxynicotinic acid)Recommanded Product: 27828-71-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Recommanded Product: Isoquinolin-6-ol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Isoquinolin-6-ol, is researched, Molecular C9H7NO, CAS is 7651-82-3, about Study of heterocyclic quinones. XXX. Isoquinoline quinones. Author is Tsizin, Yu. S.; Lopatin, B. V..

Quinones I (R = morpholino, pyrrolidinyl) were prepared in 70-92% yield by treatment of I (R = MeO) with the resp. amine ;I (R = MeO) was obtained in 80% yield by treatment of 7-methoxy-8-aminoisoquinoline with NH(SO3K)2 and NaH2PO4.H2O. II (R = morpholino, piperidino) were prepared by treating 6-hydroxyisoquinoline with Cu acetate and the corresponding base. Quinones III (R = Me, piperidino) were also prepared

This compound(Isoquinolin-6-ol)Recommanded Product: Isoquinolin-6-ol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method