Tag: M.W:100-200

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7651-82-3, is researched, SMILESS is OC1=CC2=C(C=NC=C2)C=C1, Molecular C9H7NOJournal, Tetrahedron called Synthesis of chromeno[2′,3′:4,5]imidazo[2,1-a]isoquinolines via a novel domino reaction of isoquinoline-derived immonium salts. Scope and limitations, Author is Voskressensky, Leonid G.; Festa, Alexey A.; Sokolova, Ekaterina A.; Varlamov, Alexey V., the main research direction is isoquinolinium salt preparation hydroxyarylaldehyde domino cycloaddition heterocyclization; chromeno imidazoisoquinoline preparation.Recommanded Product: Isoquinolin-6-ol.

A one-pot protocol towards chromeno[2′,2′:4,5]imidazo[2,1-a]isoquinoline derivatives, e.g., I, via a domino reaction of isoquinoline-derived immonium salts and α-hydroxy aromatic aldehydes is elaborated. The scope and limitations of this reaction is discussed.

This compound(Isoquinolin-6-ol)Recommanded Product: Isoquinolin-6-ol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Self-assembly syntheses and crystal structures of triorganotin(IV) pyridinecarboxylate: 1D polymers and a 42-membered macrocycle.SDS of cas: 27828-71-3.

A series of new triorganotin(IV) pyridinecarboxylates with 6-hydroxynicotinic acid (6-OH-3-nicH), 5-hydroxynicotinic acid (5-OH-3-nicH) and 2-hydroxyisonicotinic acid (2-OH-4-isonicH) of the types: [R3Sn (6-OH-3-nic)·L]n (I) (R = Ph, L = Ph·EtOH, 1; R = Bn, L = H2O·EtOH, 2; R = Me, L = 0, 3; R = n-Bu, L = 0, 4), [R3Sn (5-OH-3-nic)]n (II) (R = Ph, 5; R = Bn, 6; R = Me, 7; R = n-Bu, 8), [R3Sn (2-OH-4-isonic·L)]n (III) (R = Bn, 9, L = MeOH; R = Me, L = 0, 10; R = Ph, 11, L = 0.5EtOH) have been synthesized. All the complexes were characterized by elemental anal., TGA, IR and NMR (1H, 13C, 119Sn) spectroscopy analyses. Among them, except for complexes 5 and 6, all complexes were also characterized by x-ray crystallog. diffraction anal. Crystal structures show that complexes 1-10 adopt 1D infinite chain structures which are generated by the bidentate O, O or N, O and the five-coordinated tin centers. Significant O-H···O, and N-H···O intermol. hydrogen bonds stabilize these structures. Complex 11 is a 42-membered macrocycle containing six tin atoms, and forms a 2D network by intermol. N-H···O hydrogen.

《Self-assembly syntheses and crystal structures of triorganotin(IV) pyridinecarboxylate: 1D polymers and a 42-membered macrocycle》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Hydroxynicotinic acid)SDS of cas: 27828-71-3.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The determination of dissociation constants of monobasic acids. III. The strengths of some cyano acids》. Authors are Ives, D. J. G.; Sames, K..The article about the compound:2-Cyano-2-methylpropanoic acidcas:22426-30-8,SMILESS:CC(C)(C#N)C(O)=O).Recommanded Product: 22426-30-8. Through the article, more information about this compound (cas:22426-30-8) is conveyed.

Measured conductivities and the extrapolation equation were used to obtain values (given in parentheses) for, resp., the equivalent conductivity at infinite dilution at 25° (Λ0) and the thermodynamic dissociation constant (K × 105) of the following acids: cyanoacetic (387.7, 342), β-cyanopropionic (380.8, 10.2), γ-cyanobutyric (377.9, 3.66), cyclohexylcyanoacetic (371.0, 430), dimethylcyanoacetic (381.3, 380), trans-1-cyanocyclohexane-2-carboxylic (375.6, 13.65). The results are considered in relation to the structure of the acids and are correlated with existing data on the effect of substituents on acid strength. A relation between the dipole moment of the substituent and the dissociation constant of the acid is proposed; this gives good agreement between exptl. and calculated values for the cyano acids, but it can be applied only when the effect of the substituents is purely inductive in nature and when the effect of free rotation of bonds can be neglected. Preparative methods are given for all compounds

The article 《The determination of dissociation constants of monobasic acids. III. The strengths of some cyano acids》 also mentions many details about this compound(22426-30-8)Recommanded Product: 22426-30-8, you can pay attention to it, because details determine success or failure

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Computed Properties of C6H5NO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Probing the mechanism of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase by using 8-substituted-FAD analogs. Author is Sucharitakul, Jeerus; Chaiyen, Pimchai; Ballou, David P.; Massey, Vincent.

The reaction mechanism of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO) was investigated by using FAD-analogs substituted at the 8-position of the isoalloxazine ring. Replacing FAD of MHPCO with different FAD analogs having substituents at the 8-position did not greatly change the enzymic properties when compared with the native enzyme. Binding of the apoenzyme of MHPCO to the FAD analogs resulted in perturbation of the flavin absorbance and the fluorescence. The redox potential values of FAD analogs were shifted to more pos. values when bound to MHPCO. Using stopped-flow spectrophotometry, the oxidized enzyme was mixed with various concentrations of NADH, and the reaction was monitored at different wavelengths. The results indicate that the reaction of MHPCO reconstituted with FAD analogs proceeds through hydroxylation mechanisms similar to those for native enzyme.

Different reactions of this compound(5-Hydroxynicotinic acid)Computed Properties of C6H5NO3 require different conditions, so the reaction conditions are very important.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7651-82-3, is researched, SMILESS is OC1=CC2=C(C=NC=C2)C=C1, Molecular C9H7NOJournal, Article, Journal of Organic Chemistry called Metal-Free Synthesis of Phenol-Aryl Selenides via Dehydrogenative C-Se Coupling of Aryl Selenoxides with Phenols, Author is Liu, Zhengfen; Jiang, Yonggang; Liu, Chunxiang; Zhang, Linlin; Wang, Jing; Li, Tiantian; Zhang, Hongbin; Li, Minyan; Yang, Xiaodong, the main research direction is phenol aryl selenide preparation; aryl benzyl selenoxide preparation phenol cross coupling.Product Details of 7651-82-3.

Herein, we disclose the synthesis of diaryl selenides through an unexpected C-Se coupling between aryl benzyl selenoxides and phenols. The synthetic significance of the method is that it provides a mild, rapid, and metal-free access to organoselenides in high yields with excellent functional group tolerance. This coupling of aryl benzyl selenoxides reveals a completely new reaction possibility compared with aryl sulfoxides. We also probed the reaction mechanism of this unexpected transformation through exptl. studies and revealed a special Se(IV)-Se(III)-Se(II) reaction pathway.

Different reactions of this compound(Isoquinolin-6-ol)Product Details of 7651-82-3 require different conditions, so the reaction conditions are very important.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Formula: C6H5NO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Two- and three-dimensional lanthanide metal-organic frameworks with hydroxyl-functionalized nicotinic acid and oxalate ligands. Author is Zhang, Jin; Huang, Jing; Yang, Jun; Chen, Hong-Ji.

LMOFs, consisting of three groups of isostructural compounds, [Ln(3-H-5-phenoxonicotinato)(ox)(H2O)2]n 1 (Ln = La(1a), Pr(1b), Nd(1c), 5-Hydroxynicotinic acid = C6H5NO3, ox = C2O42-), {[Ln(3-H-5-hydroxynicotinato)(ox)1.5(H2O)]·H2O}n 2 [Ln = Sm(2a), Gd(2b), Tb(2c)], and {[Ln(3-H-5-phenoxonicotinato)(ox)(H2O)]·H2O}n 3 (Ln = Dy(3a), Er(3b)), were hydrothermally synthesized and structurally determined by x-ray diffraction analyses. Compounds in Group 1 are constructed by mixed μ3-3-H-5-phenoxonicotinato and oxalate bridging ligands and Ln3+ ions, exhibiting a 3-dimensional covalent network with empty 1-dimensional microchannels, featuring a 3,5-connected topol. Compounds in Group 2 present a brick-well-liked 2-dimensional network generated by both metal ions and oxalate groups at a side-by-side way. Compounds in Group 3 are isotopol. to those in Group 1, accompanying 1-dimensional microchannels being occupied by coordinated H2O mols. Antiferromagnetic interactions between Pr metal centers are observed from the magnetic susceptibility of compound 1b. Luminescence measurements indicate that the Tb complex 2c is a strong green luminescence emitter.

Different reactions of this compound(5-Hydroxynicotinic acid)Formula: C6H5NO3 require different conditions, so the reaction conditions are very important.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Reference of 5-Hydroxynicotinic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Analysis of malondialdehyde and superoxide dismustase levels after exposure of electric cigarette in rats. Author is Lisdiana; Nugrahaningsih, W. H.; Nufus, I..

Elec. cigarette (e-cigarette) is cigarette that operate on battery power to burn liquids and to produce a steam. One of the contents of an elec. cigarette is nicotine. It is a chem. compound that can cause addiction and trigger oxidative stress. This study aims to analyze the levels of malondialdehyde and superoxide dismutase in the blood of rats that exposed to nicotine from e-cigarettes. The study was conducted on 30 male Wistar rats which divided into 5 groups, control group there are neg. and pos. and treatment group with nicotine 0,25 mg, 0,5 mg, 0,75mg with exposure to cigarette smoke for 30 days. Malondialdehyde and superoxide dismutase levels measurements using the TBARs method, the results that can be known using a spectrophotometer with a wavelength of 532 nm. SOD levels were measured by the calorimetry method. The One Way Anova anal. showed that malondialdehyde and superoxide dismutase levels in the control group were significantly different from all groups. The conclusion is that nicotine has an effect on increasing malondialdehyde and decreasing superoxide dismutase levels.

Different reactions of this compound(5-Hydroxynicotinic acid)Reference of 5-Hydroxynicotinic acid require different conditions, so the reaction conditions are very important.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Cyano-2-methylpropanoic acid( cas:22426-30-8 ) is researched.Product Details of 22426-30-8.Nagarajan, Srinivasan; Ganem, Bruce published the article 《Chemistry of naturally occurring polyamines. 10. Nonmetabolizable derivatives of spermine and spermidine》 about this compound( cas:22426-30-8 ) in Journal of Organic Chemistry. Keywords: spermine analog; spermidine analog. Let’s learn more about this compound (cas:22426-30-8).

The synthesis of five gem-dimethylspermidines, e.g., H2NCMe2CH2CH2NH(CH2)4NH2, and the 2 spermine analogs H2NCMe2CH2CH2NH(CH2)4NHCH2CH2CMe2NH2 and H2NCH2CH2CMe2NH(CH2)4NHCMe2CH2CH2NH2 was described. These compounds were designed to act as polyamine oxidase inhibitors and to serve as useful probes of complex polyamine biosynthesis.

After consulting a lot of data, we found that this compound(22426-30-8)Product Details of 22426-30-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Li, Yun-xia; Xia, Yan; Lu, Ling-zhi; Feng, Yun-long published the article 《Two lead(II)-organic coordination polymers based on N-acetic-5-oxygen-nicotinic acid: syntheses, structures and fluorescence properties》. Keywords: lead coordination polymer fluorescence crystal structure.They researched the compound: 5-Hydroxynicotinic acid( cas:27828-71-3 ).Application In Synthesis of 5-Hydroxynicotinic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:27828-71-3) here.

Two new lead coordination polymers, namely, [Pb4(μ3-O)2L2]n (1), [Pb3(μ4-O)2L]n (2) (H2L = N-acetic-5-oxygen-nicotinic acid) have been prepared by the reaction of Pb(NO3)2 with H2L and characterized by elemental anal., IR and single crystal X-ray diffraction. Polymer 1 crystallizes in the monoclinic C2/c space group, and features [Pb4(μ3-O)2]n rigid inorganic chains, which are further linked by L2- ligands to form a 3D framework. Polymer 2 crystallizes in the orthorhombic P212121 space group, and displays a 3D framework with [Pb3(μ4-O)2]n inorganic chains. The thermodn. stability and fluorescence properties of 2 were investigated. CCDC: 1432217, 1; 1432218, 2.

After consulting a lot of data, we found that this compound(27828-71-3)Application In Synthesis of 5-Hydroxynicotinic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Role of the Tyr270 residue in 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti, published in 2017-02-28, which mentions a compound: 27828-71-3, mainly applied to methylhydroxypyridinecarboxylate oxygenase Mesorhizobium active site tyrosine role; crystal structure methylhydroxypyridinecarboxylate oxygenase Mesorhizobium; 2-Methyl-3-hydroxypyridine-5-carboxylic acid oxygenase; Flavoenzyme; Mesorhizobium loti; Pyridine-ring opening reaction; Tyr270; Vitamin B(6) degradation pathway I, Category: catalyst-palladium.

The flavoenzyme, 2-methyl-3-hydroxypyridine-5-carboxylate oxygenase (MHPCO), catalyzes the cleavage of the pyridine ring of 2-methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) in the presence of NADH, O2, and water. MHPCO also catalyzes the NADH oxidation reaction uncoupled with ring opening in the absence of MHPC (the basal activity). The enzyme showed activity toward not only MHPC but also 5-hydroxynicotinic acid (5HN) and 5-pyridoxic acid (5PA). The reaction rate toward 5PA was extremely low (5% of the activity toward MHPC or 5HN). The authors determined the crystal structures of MHPCO without substrate and the MHPCO/5HN and MHPCO/5PA complexes, together with a Y270F mutant without substrate and its 5HN complex. The Tyr-270 residue was located in the active site and formed H-bonds between the Oη atom and water mols. to make the active site hydrophilic. Although Tyr-270 took a fixed conformation in the structures of the MHPCO and MHPCO/5HN complex, it took 2 conformations in its 5PA complex, accompanied by 2 conformations of the bound 5PA. In the wild-type (WT) enzyme, the turnover number of the ring-opening activity was 6800-fold that of the basal activity (1300 and 0.19 s-1, resp.), whereas no such difference was observed in the Y270F (19 and 7.4 s-1) or Y270A (0.05 and 0.84 s-1) mutants. In the Y270F/5HN complex, the substrate bound ∼1 Å farther away than in the WT enzyme. These results revealed that Tyr-270 is essential to maintain the WT conformation, which in turn enhances the coupling of the NADH oxidation with the ring-opening reaction.

After consulting a lot of data, we found that this compound(27828-71-3)Category: catalyst-palladium can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method