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The use of organoborane intermediates for radiohalogenations is briefly reviewed. The synthesis of an iodine-123 labeled curcumin derivative using a newly developed radio-iodination technique is reported.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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A series of homochalcogenide and mixed-chalcogenide ligand complexes of palladium and platinum have been prepared from the reactions of Pd(dppf)Cl2, (dppf = 1,1?-bis(diphenylphosphino)ferrocene), Pd(dippf)Cl2 (1,1?-bis(diisopropylphosphino)ferrocene), and Pt(dppf)Cl2 with 1,2-benzenedithiol (HSC6H4SH) (a), 3,4-toluenedithiol (HSC6H3MeSH) (b), 3,6-dichloro-1,2-benzenedithiol (HSC6H2Cl2SH) (c), 2-mercaptophenol (HSC6H4OH) (d), thiosalicylic acid (HSC6H4CO2H) (e) and thionicotinic acid (HSC6H3NCO2H) (f). Single-crystal X-ray diffraction studies show that all complexes have distorted square-planar geometry. The complexes undergo two quasi-reversible or irreversible one-electron redox processes that involve the chalcogen ligands and diphosphinoferrocene ligands. The oxidation potentials of the chalcogen ligands increase when they bear electron-withdrawing substituents.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Convenient syntheses of substituted benzoic acids, phenols and anilines have been achieved by using palladium catalyzed cross-coupling reactions between Grignard reagents and aryl halides containing carboxy, hydroxy and amino groups without a protection-deprotection sequence.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Reference of 72287-26-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 72287-26-4, Name is [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II),introducing its new discovery.

The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The first direct arylation via C-OH bond activation of tautomerizable heterocycles has been achieved using phosphonium salts, on the basis of a combination of the phosphonium coupling and Suzuki-Miyaura cross-coupling conditions. Optimal reaction condition is obtained through screening of phosphonium salts, Pd catalysts, and bases. The direct arylation via C-OH bond activation tolerates a variety of tautomerizable heterocycles and aryl boronic acids. The mechanism of the Pd-catalyzed phosphonium coupling is proposed to proceed via a domino seven-step process including the unprecedented heterocycle-Pd(II)-phosphonium species. Application of the Pd-catalyzed direct arylation via C-OH bond activation using PyBroP leads to the most efficient synthesis of the biologically important 6-arylpurine ribonucleoside in a single step from unactivated and unprotected inosine. Copyright

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 72287-26-4, name is [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II), introducing its new discovery. Product Details of 72287-26-4

A set of fluorene oligomers has been synthesized by stepwise palladium-catalyzed (Suzuki) couplings of fluorene monomers. Ureidopyrimidinones (UPy), functional groups that can dimerize via quadruple hydrogen bonds, were attached to both ends of the oligofluorenes. The resulting bis-UPy-terminated oligomers self-assemble into supramolecular chain polymers. For comparison, oligofluorenes of the same oligomer lengths but without terminal hydrogen-bonding groups were synthesized. Chains of hydrogen-bonded fluorenes can be simply endcapped by a variety of chain stoppers, molecules that have one UPy group. In this manner, we have endcapped the hydrogen-bonded fluorene chains with either oligo(p-phenylenevinylene) or perylene bisimide. Energy-transfer experiments in solution and the solid state demonstrate that oligofluorenes can donate energy to a variety of energy acceptors, but that this energy transfer occurs most effectively when the donor fluorene is hydrogen-bonded to the acceptor.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The synthesis of 5-pinacolato-2,2?-bipyridine and its applicability in cross-coupling reactions is reported. The use of this framework in Suzuki type cross-coupling reactions, together with a recently published way to achieve indolization has been used to synthesize new spiropyran systems attached to two bipyridine moieties. The indolization method followed, is based on an ‘in situ’ hydrolysis/Fischer cyclization protocol reported by Buchwald and co-workers. The synthesis of a new phenanthroline based spirooxazine attached to a bipyridine moiety is also reported. One of the spiropyran system was used as a ligand to form a ruthenium metal complex. There photophysical properties were tested with respect to the application as sensitizer in functionalized, wire-type bridging ligands in heteronuclear metal complexes.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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This paper is concerned with the reaction of palladium complexes of the ligand 1,1?-bis(diphenylphosphino)-ferrocene which have been used to define intermediates in the cross-coupling catalytic cycle. The structure of these intermediates and their interconversion routes have been defined by 31P NMR spectroscopy. The use of 13C-labeled alkenyl iodide provide further information.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, which can effectively alleviate or treat hyperuricemia and other related diseases.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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A series of biferrocene (Fc-Fc) (1) related compounds consisting of the coupled bridged ferrocenes [3]Fc-Fc (2), [3]Fc-[3]Fc (3), [4]Fc-Fc (4), [4]Fc-[4]Fc (6), and [4]Fc-[3]Fc (5) (Fc = ferrocene and [n]Fc = [n]-ferrocenophane) has been synthesized, and intervalence electron transfer in their mixed-valence cations has been investigated. The dimers 3 and 6 are prepared by Ullmann coupling of 3-I-[3]Fc (11) and 3-I-[4]Fc (12), respectively. The unsymmetrical compounds 2 and 4 are synthesized by the cross-coupling of the above iodo derivatives with ferrocenylzinc chloride using PdCl2(dppf) as catalyst. The same catalyst is used to couple 12 with 3-ZnCl-[3]Fc to give 5. Synthesis of the iodo precursors 11 and 12 is also described. Cyclic voltammetry of compounds 1-6 in CH3CN shows two reversible one-electron processes for each of the coupled compounds. Mixed-valence ions of 1-6 are prepared by controlled current oxidation, and the intervalence-transfer bands in the near-IR are reported.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method