The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Hydroxynicotinic acid( cas:27828-71-3 ) is researched.Synthetic Route of C6H5NO3.Xu, Mingshuo; Wang, Yu; Yang, Feipu; Wu, Chunhui; Wang, Zhen; Ye, Bin; Jiang, Xiangrui; Zhao, Qingjie; Li, Jianfeng; Liu, Yongjian; Zhang, Junchi; Tian, Guanghui; He, Yang; Shen, Jingshan; Jiang, Hualiang published the article 《Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs》 about this compound( cas:27828-71-3 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: pyridinecarboxamide preparation multireceptor antipsychotic; 5-HT(1A) receptor; Antipsychotic; Multi-receptor; PCP-induced hyperlocomotion; Pyridinecarboxamide. Let’s learn more about this compound (cas:27828-71-3).
In previous study, a series of benzamides was identified as potent antipsychotic agents. As a continuation of the program to discover antipsychotics, herein we reported the evaluation of a series of pyridinecarboxamide derivatives The most promising compound I not only held good activities on dopamine D2, serotonin 5-HT1A and 5-HT2A receptors, but also exhibited low potency for α1A, H1 and 5-HT2C receptors, indicating a low propensity of side effects like orthostatic hypotension and weight gain. Furthermore, I exhibited more potent antipsychotic-like effect than aripiprazole in behavioral studies. The preliminary results were promising enough for further research around this scaffold.
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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method