Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 52522-40-4. Introducing a new discovery about 52522-40-4, Name is Tris(dibenzylideneacetone)dipalladium-chloroform
Pd-Catalyzed Decarboxylative Asymmetric Protonation of Sterically Hindered alpha-Aryl Lactones and Dihydrocoumarins
Pd-catalyzed decarboxylative asymmetric protonation (DAP) has been developed for sterically hindered alpha-aryl lactone and dihydrocoumarin substrates. Optimization studies were conducted using delta-lactone- and dihydrocoumarin-derived alpha-aryl, beta-oxo-allyl esters with 2,4,6-trimethoxyphenyl as the aryl substituent. In the absence of a chiral P,N-ligand, (1R,2S)-(?)ephedrine, a cheap and readily available chiral proton donor, induced enantioselectivities of up to 92% ee and 88% ee with lactone and dihydrocoumarin substrates, respectively. Bulky aryl groups containing di-ortho substitutions and naphthyl groups gave the highest enantioselectivities of up to 92% and 86%, respectively. A stereochemical rationale is proposed to explain the preferred sense of asymmetric induction. (Figure presented.).
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 52522-40-4, you can also check out more blogs about52522-40-4
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method