The influence of catalyst in reaction 7651-82-3

In addition to the literature in the link below, there is a lot of literature about this compound(Isoquinolin-6-ol)Category: catalyst-palladium, illustrating the importance and wide applicability of this compound(7651-82-3).

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7651-82-3, is researched, SMILESS is OC1=CC2=C(C=NC=C2)C=C1, Molecular C9H7NOJournal, Comparative Study, Article, Journal of Antibiotics called Cephalosporins having a heterocyclic catechol in the C3 side chain. II. Improvement of pharmacokinetic profile, Author is Iimura, Seiji; Imae, Kiyoto; Hasegawa, Toshifumi; Okita, Takaaki; Tamaoka, Masami; Murata, Shinji; Kamachi, Hajime; Kamei, Hideo, the main research direction is cephalosporin heterocyclic catechol preparation bactericide.Category: catalyst-palladium.

Cephalosporins I (R = H, Me; R1 = heterocyclic catechol] were synthesized. I (R = H, Me, R1 = 6,7-dihydroxyisoquinolin-2-yl) showed very high and prolonged blood levels after i.m. administration to mice and higher in vivo antibacterial activity than expected from their in vitro activity. I (R = H, R1 = 6,7-dihydroxyisoquinolin-2-yl) gave well-balanced in vitro and in vivo antibacterial spectra including anti-methicillin-resistant Staphylococcus aureus (MRSA) activity. I (R = Me, R1 = 6,7-dihydroxyisoquinolin-2-yl) also showed good in vitro and in vivo activities against Gram-pos. bacteria, especially against S. aureus A15036, a strain of MRSA, the in vivo activity being comparable to vancomycin but was lacking in anti-pseudomonal activity.

In addition to the literature in the link below, there is a lot of literature about this compound(Isoquinolin-6-ol)Category: catalyst-palladium, illustrating the importance and wide applicability of this compound(7651-82-3).

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method