Formula: C9H7NO. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Isoquinolin-6-ol, is researched, Molecular C9H7NO, CAS is 7651-82-3, about Electronic effects in isoquinoline systems. Author is Zielinski, Wojciech; Kudelko, Agnieszka; Mazik, Monika.
Values of pKa for 1-(N,N-dimethylamino)-3-methylisoquinoline and a series of their 6- and 7-substituted derivatives, 3-methylisoquinoline and 1-amino-3-methylisoquinoline were determined in 50% volume/volume aqueous-methanolic solution by the spectrophotometric method. The determined values of pKa and values of pKa for 1-phenyl-3-methylisoquinolines and 1,3-dimethylisoquinolines taken from literature were correlated with the Hammett σ constants Good correlations were obtained for 6-substituted derivatives with σp constants and for 7-substituted derivatives with σm constants The electronic effects occurring in the studied isoquinoline systems made by substituents present in pyridine and benzene ring are discussed basing on the determined values.
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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method